Massachusetts General Hospital Boston United States
The Research Project supported by this DOD Award investigates the potential of in vivo and ex vivo MRS in characterizing the metabolomic spectra of TSC-associated lipid poor renal masses. After a brief delay in IRB approval, which led to a later than expected start to our subject enrollment we have proceeded with in vivo and ex vivo MRS of renal masses in patients with TSC. In an effort to optimize our in vivo image acquisition protocol, we began by scanning healthy volunteers. Subsequently, our overall enrollment of TSC patients with lipid poor renal masses has been lower than expected. For this reason and in order to meet our goals of gaining more metabolomic data on renal masses, we have expanded our subjects to include TSC patients with lipid rich masses, non-TSC patients with lipid poor and lipid rich renal masses. We continue to enroll patients and analyze our current and ongoing data.