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Volumetric Characteristics of Idiopathic Pulmonary Fibrosis Lungs: Computational Analyses of High Resolution Computed Tomography Images of Lung Lobes

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Biotechnology HPC Software Applications INST Fort Detrick United States

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Background Idiopathic pulmonary fibrosis IPF is a fatal lung disease involving progressive degeneration of lung capacity. Current diagnosis of IPF heavily relies on visual evaluation of fibrotic features in high-resolution computed tomography HRCT images of the lungs. Although the characteristics of this disease have been studied at the molecular and cellular levels, little is known about the mechanical characteristics of IPF lungs inferred from HRCT images. To this end, we performed a pilot study to investigate the radiographic and volumetric characteristics of lungs in subjects with IPF. Methods We collected HRCT images of healthy N 13 and IPF N 9 lungs acquired at breath-holds after full inspiration expanded state and full expiration contracted state. We performed statistical analyses on Hounsfield unit HU histograms, lobar volumes V lobe volume normalized by the lung volume, and lobar flows Q the difference in lobe volume divided by the difference in lung volume between the expanded and contracted states.

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Journal Article - Open Access

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Respiratory Research , 20, 01 Jan 0001, 01 Jan 0001, This article is distributed under the terms of the Creative Commons Attribution 4.0International License (, which permits unrestricted use, distribution, andreproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link tothe Creative Commons license, and indicate if changes were made



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