The Johns Hopkins University Baltimore United States
More than half of the combat-related injuries per peer reviewed analyses of the Joint Theater Trauma Registry sustained by Warfighters in Iraq and Afghanistan involved extremities or craniofacial structures. An estimated 40 of all combat casualties in Operation Enduring Freedom OEF and Operation Iraqi Freedom OIF resulted in injuries to the extremities, face, and head and neck structures. Vascularized composite allotransplantation has increasingly become a viable clinical treatment option for the treatment of complex craniofacial and limb defects. To date, more than 100 patients worldwide have benefited from VCA, the majority receiving hand or face transplants. However, the transformational potential of VCA is severely limited by short preservation times 4 -6 hours. This work will deliver ex vivo VCA perfusion technology intended to extend preservation time to 24 hours and minimize ischemia damage by efficient perfusion and multi-parametric monitoring.