DID YOU KNOW? DTIC has over 3.5 million final reports on DoD funded research, development, test, and evaluation activities available to our registered users. Click
HERE to register or log in.
Accession Number:
AD1062928
Title:
Controlling Mitochondrial Dynamics to Mitigate Noise-Induced Hearing Loss
Corporate Author:
Oregon Health and Science University Portland United States
Report Date:
2018-10-01
Abstract:
In this study, we are examining the efficacy of a potential early intervention therapeutic for noise induced hearing loss NIHL.The generation of reactive oxygen species is one of the underlying mechanisms of noise-induced damage to tissues in the innerear that leads to noise-induced hearing loss NIHL. The goal is to define an effective post-exposure, non-invasive intervention strategy to mitigate a primary cause of loud-sound induced hearing loss mitochondrial dysfunction and overproduction of reactive oxygen species. Utilizing a small molecule mitochondrial fission inhibitor, mitochondrial division inhibitor-1, the results so far have demonstrated that inhibition of the mitochondrial fission process significantly attenuates NIHL and reduces damage to the tissues of the inner ear resulting from a single acute sound exposure.
Descriptive Note:
Technical Report,14 Sep 2017,15 Sep 2018
Pages:
0022
Distribution Statement:
Approved For Public Release;
File Size:
2.95MB
