University of California, San Francisco San Francisco United States
Early management of blood pressure BP may be critical to outcome after spinal cord injury SCI, but evidence-based protocols are needed. Optimal early treatment and management of SCI has not been established in clinical practice, nor in animal models. Guidelines for management of BP in acute SCI have been influenced by evidence of a relationship between hypotension and poor outcomes in TBI, and the aim of maintaining cerebral blood flow in then face of increased intracranial pressure ICP, but doubt remains about what is best for SCI. This grant focuses on the following two hypotheses 1 Episodes of low BP measured by mean arterial pressure MAP and systolic BP in the early management of clinical SCI predict worse long-term functional outcomes, and 2spontaneous hypotensive episodes in the perioperative period of experimental SCI in rats will result in worse outcomes. Both clinical data and experimental modeling studies address these specific hypotheses.