Cedars-Sinai Medical Center Los Angeles United States
In this annual report covering initiating and collaborating PI projects we report the completion of initial experiments investigating the effect of whole body and focal GI tractirradiation of mice on the bacterial and fungal microbiota. We have identified substantial changes in intestinal microbial communities induced by both types of radiation exposure. In particular, specific fungal community changes appear to be pronounced and relatively long-lived. As outlined in the project proposal, we are now embarking on experiments aimed a evaluating the effects of these changes on intestinal susceptibility to inflammatory disease.