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Defining the Pathophysiological Role of Tau in Experimental TBI

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University of Pennsylvania Philadelphia United States

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After traumatic brain injury TBI, the human brain sometimes develops tau pathology partly resembling the hallmark neuropathological features of the tauopathy of Alzheimers disease AD. Although tau has been strongly linked to the pathogenesis of AD, its involvement in the pathophysiology of TBI and its influence on brain structural and functional outcomes are unclear. Here we used a novel mouse model of early stage AD-type tauopathy to critically evaluate three hypotheses i tau exacerbates the neuronal damage and cognitive dysfunction after single and repetitive mild TBI in the acute and chronic post-injury periods ii mild TBI promotes the severity and spread of tau pathology to contribute to development of a chronic neurodegenerative disorder and iii novel biomarkers for neurodegeneration are non-invasive blood measures of brain dysfunction valuable for the diagnosis and prognosis of mild TBI-triggered chronic neurodegenerative disease.

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Technical Report,30 Sep 2016,29 Sep 2017



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Approved For Public Release;

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