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Accession Number:
AD1046477
Title:
Examination of plasma PON1 paraoxonase activity and genotype in Gulf War veterans
Corporate Author:
NCIRE San Francisco United States
Report Date:
2017-10-01
Abstract:
The goal of this project is to evaluate the extent to which PONsub1192Gulf War GW-related exposure interactions contribute to the risk for Gulf War Illness GWI, as defined by the Centers for Disease Control and PreventionCDC and Kansas case definitions in a large sample of GW veterans. Specifically, we will 1 determine the associations between GWI and GW-related exposures with the potential for cholinergic effects e.g., personal pesticide use, exposure to OP nerve agents in subgroups of veterans with different PONsub1192 genotype. 2determine the associations between GWI and each GW-related cholinergic exposure in subgroups of veterans with different PON1 activity levels and 3 calculate prevalence odds ratios for GWIexposure associations separately for subgroups of veterans with different PONsub1192 genotypes and PON1 activity levels.
Descriptive Note:
Technical Report,30 Sep 2016,29 Sep 2017
Pages:
0017
Distribution Statement:
Approved For Public Release;
File Size:
0.12MB
