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Accession Number:
AD1046135
Title:
Inflammation as a Driver of Clonal Evolution in Myeloproliferative Neoplasm
Corporate Author:
University of California, Irvine Irvine United States
Report Date:
2017-10-01
Abstract:
Tumor Necrosis Factor-alpha TNF is elevated in myeloproliferative neoplasm MPN and plays a key role in expansion of the JAK2V617F neoplastic clone. We have found that MPN monocytes produce excessive amounts of TNF in response to TLR ligation due to a defect in the negative regulatory feedback loop which normally serves to dampen TNF production. We have localized this defect to a blunted response to the anti-inflammatory cytokine IL-10. MPN monocytes are less responsive to the anti-inflammatory actions of IL-10 at low concentrations but these effects can be restored by increasing the concentration of IL-10.Together, these data suggest that administration of IL-10 may reduce excessive inflammatory cytokine production in MPN.
Descriptive Note:
Technical Report,15 Sep 2016,14 Sep 2017
Pages:
0017
Distribution Statement:
Approved For Public Release;
File Size:
0.77MB
