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Cancer Risks Associated With Inherited Mutations in Ovarian Cancer Susceptibility Genes Beyond BRCA1 and BRCA2

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University of Washington Seattle United States

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Ovarian, peritoneal and fallopian tube carcinomas OC are the most deadly of the gynecological cancers. Our data indicate that at least 20 of unselected OC is hereditary and that 20-25 of inherited mutations occur in genes other than BRCA1 and BRCA2. The large fraction of OC associated with inherited mutations in a variety of genes provides an important opportunity to reduce OC mortality. Maximizing the benefit from OC risk assessment and prevention requires an improved understanding of the penetrance of OC genes beyond BRCA12. Furthermore, minimal data exist regarding the hereditary component of OC, including BRCA12, in non-white populations. The objective of this study is to define the genetic causes of hereditary OC in African Americans AA as well as the spectrum of cancers, the age of onset, and the relative risk associated with mutations in non-BRCA12 genes. In year 2, we have enrolled an additional 98 high risk probands and 8 AA probands with OC for BROCA sequencing of 45 known or candidate OC genes. We continue to enroll probands and their relatives to better understand the genetic contribution to ovarian cancer and will focus on exome sequencing 30 families in year 3.

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Technical Report,15 Apr 2016,14 Apr 2017



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Approved For Public Release;

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