Kaiser Foundation Research Institute Oakland United States
The objective of this study is to identify histologic characteristics and molecular markers associated with an increased risk of colorectal cancer in patients with sessile serrated colorectal polyps SSPs. The projects specific aims are as follows 1 Estimate the risk of colorectal cancer or advanced polyps in patients who have SSPs with cytological dysplasia compared to patients with SSPs that lack cytological dysplasia and 2 Evaluate if the risk of incident colorectal cancer or advanced polyps varies according to methylation markers in SSPs. The following progress was made during years 1 and 2 Human Subjects approval was obtained from all institutions, SSPs with subsequent colorectal neoplasia and interval cancers were identified, the pathology review form and protocol were finalized, assays for methylation markers were optimized, tissue slide and block pulling and the standard pathology reviews were completed, data cleaning of the pathology review data was finished and analyses of these data begun, tissue sectioning was completed on 85 of samples, and DNA extraction was completed on 60 of samples. Also, Dr. Burnett-Hartman participated in regular career development opportunities, including attending clinical research seminars, presenting at national and local research meetings, and continued to connect with new clinical partners at Kaiser Permanente Colorado. Dr. Burnett-Hartman also maintained regular meetings with mentors and collaborators at the Fred Hutchinson Cancer Research Center, the University of Washington, and Kaisers Institute for Health Research.