Oregon Health and Science University Portland United States
A history of TBI increases the odds of developing AD by 2.5 times in the general population, and 4-6 times for military veterans. Although significant associations between mTBI and risk of AD have been observed, the precise mechanism by which TBI might lead to AD andor AD-related symptoms are not yet understood. Histologically, AD is characterized by amyloid- and neurofibrillary protein aggregates, suggesting a loss of protein processing is a key feature of AD. MiRNAs are small non- coding RNA that regulate mRNA transcription, and may be a significant cause of protein dysregulation. To date, we have established molecular biology techniques that allow us to measure miRNA in CSF from living donors. We have established and validated a biostatistical pipeline to identify biomarker candidates from our assay. We are building a bioinformatics pipeline to associate altered miRNA signatures with predicted changes in mRNA regulation, that may link altered miRNA with AD-related pathologies.