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Gestational Exposure to Soy Isoflavones and Epigenetic Regulation of Breast Cancer Risk

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The University of Arizona Tucson United States

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The overarching challenge is to identify what makes the breast susceptible to cancer development, and more specifically, the mechanisms that link epigenetic silencing of the BRCA-1 gene to the development of triple-negative breast cancers TNBC. The main purpose of this project is to examine whether the DNA methyltransferase DNMT inhibitor and soy isoflavone, genistein prevents CpG methylation of the BRCA-1 gene and development of TNBCs. Major findings Preliminary data acquired through the support of this grant indicate that 1 in cell culture experiments with ER-positive breast epithelial cells genistein exerted dose- and time dependent preventative effects on repression of BRCA-1 expression.

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Technical Report,30 Sep 2015,29 Sep 2016



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Approved For Public Release;

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