Accession Number:

AD1041555

Title:

Rescue of TET2 Haploinsufficiency in Myelodysplastic Syndrome Patients Using Turbo Cosubstrate

Personal Author(s):

Corporate Author:

University of Missouri System Kansas City United States

Report Date:

2017-07-01

Abstract:

During this period, we have demonstrated that 2-oxoglutarate 2OG analogs can dramatically enhance the activity of TET2 enzymes from MDS patient. Further, we published a manuscript on convenient expression, purification and quantitative liquid chromatography-tandem mass spectrometry-based analysis of TET2. Finally, we have identified novel substrate specificity of TET2 oxygenase.

Descriptive Note:

Technical Report,20 Jun 2016,19 Jun 2017

Pages:

0018

Subject Categories:

Communities Of Interest:

Distribution Statement:

Approved For Public Release;

File Size:

1.47MB