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Study the Effect of KSL-W on Inflammatory Response of Engineered Human Oral Mucosa Following Candida albicans Infection

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University of Laval Quebec Canada

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Candida species are the most common opportunistic fungal pathogens in humans, with C.albicans being the most prevalent pathogen in mucosal and systemic fungal infections Pfaller etal., 2002 Trick et al., 2002. The C. albicans fungus causes both systemic and local disease. Fungal invasion of the superficial oral epithelial cells is a characteristic of oropharyngeal candidiasis Farah et al., 2000 Eversole et al., 1997 Drago et al., 2000. C. albicans invasion of host cells, such as oral epithelial cells, is necessary for the organism to damage these cell types invitro Filler et al., 1995 Park et al., 2005. Host cell invasion and damage are likely critical virulence attributes of C. albicans Park et al., 2005 Phan et al., 2000.

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