We are developing a device consisting of multiple parallel microcantilevers that will be used to detect pathogens in fluid-based environments. These microfabricated devices will allow water samples to be surveyed and monitored in real time. They will be highly sensitive and extremely accurate. The parallel MEMS cantilever-based platform that we are developing is based on nucleic acid pathogen signatures that are identified using software that we have developed. The initial prototype devices have low background and exquisite sensitivity to test target sequences. The completed devices are expected to allow the detection of small numbers of pathogens with a high degree of confidence. With the combined expertise of life scientists, engineers, and computational biologists, MPRI is uniquely positioned to develop, expand, and oversee this project.