The overall goal for the Johns Hopkins RTR Consortium is to advance translational research of the most clinically pertinent issues of Restorative Transplantation through a multidisciplinary collaboration among highly experienced and accomplished partners. The Consortium has thus assembled three complimentary, multidisciplinary research projects from Johns Hopkins, Massachusetts General Hospital and University of Pittsburgh. Each of the individual projects has made significant progress during this reporting period. The Initiating Site through their coordinated efforts has facilitated that all projects are mostly on track with the proposed statements of work. The group has met all Major Tasks for Year 2, in particular we have assisted sites with ACURO and HRPO submissions, contacted sites to remind them of upcoming Quarterly Report deadlines, Collected and Reviewed Quarterly Reports and held update calls to discuss progress among project leaders.