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Combined Effects of Primary and Tertiary Blast on Rat Brain: Characterization of a Model of Blast-Induced Mild Traumatic Brain Injury

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The Geneva Foundation Tacoma United States

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We hypothesize that the biomechanical perturbations of the brain that yield blast-induced mTBI in injured warfighters can be recreated with reasonable fidelity in rats under carefully controlled experimental conditions, and that several of the characteristic sequelae of blast-induced mTBI observed clinically can be reproduced in a rodent injury model. In many, if not most circumstances yielding blast mTBI, brain injury results from a combination of blast overpressure BOP i.e. primary blast and head acceleration andor impact i.e. tertiary blast. The mTBI resulting from these combined insults may be fundamentally different from that seen from either insult alone.

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Technical Report,01 Mar 2011,28 Feb 2016



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Approved For Public Release;

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