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Accession Number:
AD1031293
Title:
Drosophila as a Screening Platform for Novel Lung Cancer Therapeutics
Corporate Author:
Icahn School of Medicine at Mount Sinai New York United States
Report Date:
2016-09-01
Abstract:
The research in this grant is designed to explore the effects of genetic and genomic complexity in lung cancer progression and response to therapeutics. Using Drosophila, we are establishing a set of personalized fly lines, each which represents a separate patient. In this Progress Report, I discuss our initial studies in building these lines. In addition, I discuss our results with screening a library of 1200 FDA approved drugs. We provide evidence that a two drug cocktail, trametinib plus fluvastatin, synergize to improve efficacy and minimize toxicity in fly and human cell line models.
Descriptive Note:
Technical Report,01 Sep 2015,31 Aug 2016
Pages:
0027
Distribution Statement:
Approved For Public Release;
File Size:
3.72MB
