Spaulding Rehabilitation Hospital Charlestown United States
The purpose of this project is to study the effects on bone health of exoskeleton-assisted gait in individuals with a complete spinal cord injury. Advanced biomechanical models of human locomotion are utilized to estimate the mechanical effects of the dynamic loading of the bone structures that takes place during exoskeleton-assisted gait. The estimated maximum energy equivalent strain is studied as a potential proxy of bone adaptation and correlated with high-resolution peripheral quantitative computed tomography data and with clinical measures e.g. biomarkers of inflammation such as C-reactive protein and IL-6 that are collected longitudinally. The research team has developed advanced biomechanical models to study the biomechanics of exoskeleton-assisted gait and derive estimates of loads applied to the bones. The research team continues to recruit study volunteers.