Trustees of the University of Pennsylvania Philadelphia United States
This report describes continued work on the award Neurocognitive Effects of Radiotherapy, which examines the neurocognitive and imaging impact of proton therapy for patients will low grade glioma and base of skull meningioma. A total of 58 patients have been enrolled. All cohort 1 and 2 patients have completed a 4-5 hour neurocognitive testing assessment at baseline by Dr. Carol Armstrong. In addition, cohort patients have completed a 1 hour standard MRI as well as additional testing including diffuse tensor imaging DTI, perfusion and diffusion. The majority of patients have completed baseline and at least three additional time-points in regards to both neurocognitive testing and MRI. Eighteen patients have completed neurocognitive and imaging evaluation at planned timepoints. Dr. Michelle Alonso-Basanta is Principle Investigator for this. Catherine Feinstein is the Clinical Research Coordinator managing the associated IRB-approved protocol. Dr. Christine Hill-Kayser is the Project Manager for this section of the award. Further budgetary details are outlined in the attached document.