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Hadamard Transform Time-of-Flight Mass Spectrometry

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Department of Chemistry Standford University Standford United States

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Mass spectrometry MS is a powerful analytical tool for determining the structural and chemical identities of a broad array of analytes that can be converted to gas-phase ions. MS possesses the advantages of rapid data acquisition, sensitivity, large dynamic range, and selectivity. Though different instruments employ different specific measurement principles, all mass spectrometers share the common goal of measuring parameters that can be converted to a histogram of mass-to-charge ratios. This goal is achieved through the manipulation and monitoring of ions exposed to known electric andor magnetic fields . Unlike many other analytical techniques, mass spectrometry is completely general any chemical species that can be made into a stable gas-phase ion can be analyzed. Ion source technologies, methods to produce gas-phase ions, have advanced rapidly. These new methods enable gas-phase ion generation from most types of chemical samples from both the solution-phase and the solid-phase without the need for any labeling or chemical derivatization.

Descriptive Note:

Technical Report,01 Apr 2007,30 Oct 2009



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Approved For Public Release;

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