Accession Number:

AD1018688

Title:

Nanosizing a Metal-Organic Framework Enzyme Carrier for Accelerating Nerve Agent Hydrolysis

Personal Author(s):

Corporate Author:

NORTHWESTERN UNIV EVANSTON IL EVANSTON United States

Report Date:

2016-10-05

Abstract:

We report the synthesis and characterization of a water-stable zirconium metal-organic frameworkMOF, NU-1003, featuring the largest mesoporous aperture known for a zirconium MOF. This material has been used to immobilize the nerve agent hydrolyzing enzyme, organophosphorus acid anhydrolase OPAA. The catalytic efficiency of immobilized OPAA in nanosized NU-1003 is significantly increased compared to that of OPAA immobilized in microsized NU-1003 and even exceeds that of the free OPAA enzyme. This paper highlights a method for rapid and highly efficient hydrolysis of nerve agents using nanosized enzyme carriers.

Descriptive Note:

Journal Article

Supplementary Note:

ACS Nano , 10, 10, 01 Jan 0001, 01 Jan 0001, Open Access: Publishers Version. May be placed on public websites; ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.

Pages:

0009

Descriptors:

Identifiers:

Communities Of Interest:

Distribution Statement:

Approved For Public Release;

File Size:

5.31MB

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