NORTHWESTERN UNIV EVANSTON IL EVANSTON United States
We report the synthesis and characterization of a water-stable zirconium metal-organic frameworkMOF, NU-1003, featuring the largest mesoporous aperture known for a zirconium MOF. This material has been used to immobilize the nerve agent hydrolyzing enzyme, organophosphorus acid anhydrolase OPAA. The catalytic efficiency of immobilized OPAA in nanosized NU-1003 is significantly increased compared to that of OPAA immobilized in microsized NU-1003 and even exceeds that of the free OPAA enzyme. This paper highlights a method for rapid and highly efficient hydrolysis of nerve agents using nanosized enzyme carriers.
ACS Nano , 10, 10, 01 Jan 0001, 01 Jan 0001, Open Access: Publishers Version. May be placed on public websites; ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.