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Identification of miRNA Signatures Associated with Epithelial Ovarian Cancer Chemoresistance with Further Biological and Functional Validation of Identified Key miRNAS

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Case Western Reserve University Cleveland

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Heretofore, efforts to develop implantable sensors for real-time clinical monitoring of glucose subcutaneously SQ in diabeticpatients have been hindered by the unreliable analytical results owing largely to biocompatibility problems induced by sensorimplantation e.g., inflammatoryforeign body response. The goal of this research program has been to explore and optimizethe chemistries required to fabricate implantable amperometric glucose sensors with outer polymeric coatings that slowlygenerate low levels of nitric oxide NO. Release of NO has been shown to enhance the biocompatibility of the implantedsensors by decreasing the inflammatory response. The focus of this research has been to develop new polymeric coatingsbiomedical hydrogels and polyurethanes that possess immobilized copper ions or organoselenium and organotelluriumspecies that will serve as catalytic sites for in situ conversion of endogenous nitrosothiol species RSNO to NO, therebyproviding local generation of NO species at the surface of the implanted sensors. Preliminary biocompatibility experimentssuggested that RSNO levels within the SQ fluid of rats may be sufficient to generate enough local NO to reduce theinflammatory response at the implant site. New needle-type sensors were explored to determine the levels of RSNOs in theSQ region. Finally, functional needle-type SQ glucose sensors have been prepared with NO generation coatings. Thesesensors provide the basis for determining that the new NO generation chemistries are compatible with the electrochemicalglucose sensing chemistries.

Descriptive Note:

Technical Report,15 Jul 2011,29 Jan 2016



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Approved For Public Release;

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