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Ex Vivo Machine Perfusion in CTA with a Novel Oxygen Carrier System to Enhance Graft Preservation and Immunologic Outcomes

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University of Pittsburgh Pittsburgh United States

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The objective of this proposal is to establish the graft preservation and immunomodulatory effects of our MP-BMPSHBOC system in a pre-clinical large animal CTA model. We will specifically address the following specific aims in a porcine vascularized musculo-adipo-cutaneous flap model Aim 1 Does MP-BMPSHBOC allow prolongation of CIT without significant cellular damage to the allograft Aim 2 Does the MP-BMPSHBOC minimize the effects and incidence of ischemia-reperfusion injury at revascularization Aim 3 What is the effect of MP-BMPSHBOC on the immune profile of various flap tissues after transplantation

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Technical Report,15 Sep 2014,14 Sep 2015



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Approved For Public Release;

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