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Autism and Obesity: Co-Occurring Conditions or Drug Side Effects

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Children's Mercy Hospital Kansas City United States

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1 IRB protocol has been submitted and an Exempt status has been determined for the project. 2 WeightHeight data has been obtained from the AGRE database and BMI has been calculated for autistic subjects n552. Autistic subjects were then classified based on the BMI data into obese, overweight, healthy and underweight categories. 3 Using a rigorous literature search dbSNP search, we collected data on 157 AIWG SNPs and used multiple tools and selection criteria to identify Tag SNPs for these SNPs. 4 We found SNAP SNP Annotation and Proxy Search tool to be the most useful for selecting Tag SNPs. 5 We downloaded AGRE genotyping data combined Affymetrix and Illumina platforms. We are examining this genotyping list for the presence of the AIWG Master List SNPs and the identified Tag SNPs. 6 We began developing a statistical pipeline for analyzing the genotyping data bioequivalence tests. A poster was presented at the annual ASHG meeting summarizing the current status of our statistical method.

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Technical Report,30 Sep 2014,29 Sep 2015




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Approved For Public Release;

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