Accession Number:

AD1003203

Title:

Psychosocial Stress and Ovarian Cancer Risk: Metabolomics and Perceived Stress

Personal Author(s):

Corporate Author:

Brigham and Women's Hospital, Inc. Boston United States

Report Date:

2015-10-01

Abstract:

Mouse models suggest that chronic stress promotes ovarian tumorigenesis, but the relationship between stress and ovarian cancer has never been evaluated in humans. In our analysis of self-reported stress and risk of ovarian cancer, we noted that phobic anxiety and social isolation were suggestively associated with increased risk of ovarian cancer hazard ratios of 1.14 and 1.24, respectively. Depression was significantly associated with increased ovarian cancer risk hazard ratio 1.26, as was being widowed hazard ratio 1.38. Taken together, these data are consistent with animal data demonstrating the adverse impact of chronic stress on ovarian cancer risk.

Descriptive Note:

Technical Report,30 Sep 2014,29 Sep 2015

Pages:

0007

Descriptors:

Identifiers:

Distribution Statement:

Approved For Public Release;

File Size:

0.18MB

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