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Cell Proliferation After Irradiation.

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Both biological and physical aspects of radiation dosimetry were considered in this study. The biological dosimetry involved specific patterns of hemopoiesis following irradiation, especially erythropoiesis. Three groups of animals were used for this experiment. Group I, the control group received no irradiation and each animal was given 13.2 microcurieskg of glycine-2-C-14 intravenously. Group II received the same amount of C-14 glycine as the control group immediately following irradiation from a Co-60 source. Group III was injected with the labeled glycine on the fourth day following the exposure to the Co-60 source. Identical exposures were experienced by Groups II and III 50 R, 100 R, 200 R, 600 R, and 800 R. Exposure rates of 53 Rmin were made at a point corresponding to the mid-line of the animal. With damage to the stem cell compartment, the red cell renewal system will give a cell population which will be an indicator of residual injury. This injury was shown to be dose dependent. Part two of this study illustrates the energy dependence of depth dose patterns to gamma or X-rays. A detailed study is presented comparing the efficiency of a solid state thermoluminescent dosimetry system to that of a previously proven tissue equivalent inoization chamber. Absorbed dose measurements indicate variances in dose due to changes in animal configurations, especially with exposures made with lower energies. In-vivo measurements relate accurate depth does determinations with the use of LiF in teflon dosimeters. Author

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Technical rept. Nov 66-Jun 68,




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