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Accession Number:
AD0843865
Title:
Cytotoxicity of Virus
Corporate Author:
ARMY BIOLOGICAL LABS FREDERICK MD
Report Date:
1968-01-03
Abstract:
Cytotoxic effects through virus capable of propagation such as those of the pox group inactivated by ultraviolet exposure, were produced under high virus-cell ratios in various cell cultures. In the inoculated culture systems, these effects do not propagate in stages and cannot be transferred to new cultures. The cytotoxic effect was linked to the virus particles. The changed cultures do not show any observable virus propagation. Comparison of three members of the pox group, in relation to cytotoxicity and virus propagation in various cultures, indicates that the cells propagate virus to greater or lesser extent or not at all whereas the conditions for cytotoxicity are very probably uniform in all members of the group. There was no correlation between these two virus effects. In regard to virus propagation, the individual types are different from each other in different cell systems but act uniformly in regard to cytotoxicity, independently of the cell system.
Supplementary Note:
Trans. of Zeitschrift fuer Hygiene und Infektionskrankheiten (West Germany) v151 p185-198 1965.
Pages:
0022
Distribution Statement:
Approved for public release; distribution is unlimited.
File Size:
1.03MB
