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Accession Number:
AD0843483
Title:
The Sensitivity of Guinea Pigs to Penicillin
Corporate Author:
ARMY BIOLOGICAL LABS FREDERICK MD
Report Date:
1967-10-20
Abstract:
The studies provide an insight into the significance of nutritive factors in the pathogenesis of toxic effects of penicillin. In practice, elimination of green fodder cauliflower leaves leads to a reduction in penicillin tolerance which is, however, not solely due to a lack of Vitamin C, since even manifold overdosage of ascorbic acid does not compensate the complex of toxic symptoms which develops through omission of green fodder. It can be surmised that cabbage leaves contain specific effective substances which are able to raise the limit of tolerance of guinea pigs towards penicillin. Tissue water deprivation caused by withdrawal of green fodder cannot in itself be decisive since the addition of fluids in the form of oatmeal gruel causes only a temporary increase in weight which is again followed by weight loss.
Descriptive Note:
Preliminary rept.
Supplementary Note:
Trans. of Zeitschrift fuer Haut- und Geschlechtskrankheiten (West Germany) v14 p210-215, 1953.
Pages:
0008
Distribution Statement:
Approved for public release; distribution is unlimited.
File Size:
0.28MB
