There are remarkable facilities for serological reactions applicable to diagnosis of syphilis. In practice one should choose a limited number of reactions done with strict technical exactness in the presence of adequate controls. In the vast majority of cases, the cardiolipidic reactions answer to the requirements of clinical examination and epidemiology. The Nelson test -- of remarkable specificity and used especially for study of litigous cases -- remains the reference reaction. After a long period of isolation, the serology of syphilis has come back into the framework of immunology of bacterial maladies. The presence of antibodies is linked to the presence of the treponema. However, no serological method, no matter how highly perfected, is completely immune from failure. Only close cooperation between clinician and biologist gives to serodiagnosis of syphilis all its significance and value.
Trans. of Revue du Praticien (France) v14 p1815-1818, 1821-1824, 1827-1828, 1831-1834, 1964.