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Accession Number:
AD0843448
Title:
The Serodiagnosis of Syphilis by Immunofluorescence (In Regard to 207 Examined Sera)
Corporate Author:
ARMY BIOLOGICAL LABS FREDERICK MD
Report Date:
1968-02-04
Abstract:
The serum of a syphilitic subject contains antitreponema antibodies which are globulins. If one fixes a treponeme for example treponemes of Nichols strain, identical to those used in Nelsons test and obtained by passages through rabbit testicles suspension on a slide, these globulin-antibodies will fix themselves on the spirochete, but also act as antigen for an antiglobulin-human serum which also fixes itself on the treponeme antigen-antibody complex. Since the antiglobulin-human serum is combined with a fluorescein derivative, the treponeme becomes fluorescent under ultraviolet examination. On the other hand, in the absence of antibody, that is to say in the study of a nonsyphilitic serum, the antiglobulin is not fixed and the antigen remains nonfluorescent.
Supplementary Note:
Trans. of Societe de Medecine Militaire Francaise. Bulletin Mensuel, v58 p282-287 1964.
Pages:
0008
Distribution Statement:
Approved for public release; distribution is unlimited.
File Size:
0.36MB
