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Accession Number:
AD0838829
Title:
SMALL PLAQUE MUTANTS OF THE SINDBIS VIRUS
Corporate Author:
ARMY BIOLOGICAL LABS FREDERICK MD
Report Date:
1965-11-05
Abstract:
In embryo cell cultures in gel medium infected with the Sindbis virus, two types of plaques appear large G and small p plaques. The G plaques appear in 24 hours and grow until they attain a diameter of more than 20mm. The small plaques p appear after 48 hours but never attain a diameter exceeding 3mm. After three successive reinoculations stable sub-lines of the p type are obtained, while the G sub-lines always give rise to a predominance of G but a small, constant percentage of p plaques. The interpretation of this phenomenon is that a mutation is spontaneously occurring, giving rise to small- plaque mutants from clones of wild-type, large-plaque viruses.
Supplementary Note:
Trans. of Institut Pasteur, Paris. Annales (France) v107 p598-603 1964. DOI: 10.21236/AD0838829
Pages:
0009
Distribution Statement:
Approved for public release; distribution is unlimited.
File Size:
0.36MB
