With regard to the clinical symptomatology there was observed in all three cases a febrile condition that lasted from three weeks to four months with an enlargement of the spleen and anemia with leukopenia, whereupon the lethal termination occurred in a condition of emaciation. These clinical symptoms are considered typical for the severe disease. The diagnosis of histoplasmosis was established microscopically as a result of discovering yeast-like bodies and also Histoplasma capsulatum in the reticulo-endothelial cells of the tissues, particularly in the lungs. In the lung tissue, in addition to fungus spores, the presence of numerous treadlike mycelia was detected along with pseudomycelia and the formation of blastospores or arthrospores.
Trans. of Arkhiv Patologii (USSR) v18, n7, p84-92, 1956.