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Accession Number:
AD0838273
Title:
DEMONSTRATION OF ANTHRAX BACILLI AFTER IMMUNIZATION WITH CARBOZOO
Corporate Author:
FORT DETRICK FREDERICK MD
Report Date:
1968-07-01
Abstract:
Eight out of 39 rabbits 20.51 sacrificed after pre-treatment with bovine or ovine doses of Carbozoo vaccine yielded anthrax bacilli in the edema at the injection site in 4 cases in 2 cases after 4 hours, in one case after 8 hours, in another after 4 days, in the regional lymph gland in one case after 5 days and in all organs in 2 cases after 4 and 8 days, respectively. In the last 2 cases the rabbits had succumbed to advanced coccidiosis prior to the planned sacrifice and revealed anthrax bacilli in septicemic dissemination. The remaining animals 79.49, tested a few hours to 14 days after inoculation with Carbozoo, yielded no anthrax bacilli either at the injection site, in the regional lymph gland, or in the spleen, liver, kidneys and the heart blood. The demonstration of precipitinogen in the dried skin of rabbits apparently healthy at the time of sacrifice succeeded in 4 cases, 4 and 36 hours and 2 and 4 days after inoculation, respectively, but only in extracts prepared from skin particles from the site of injection. The occurrence of anthrax bacilli in the milk and urine of 3 cows immunized with Carbozoo could not be observed on the 1st, 2d, 3rd, 4th, 6th, 7th, 8th 9th and 10th day p.i. Nor did supplementary tests produce the pathogen from the injection site of these 3 cows on the 6th, 8th, 9th, 10th and 11th day.
Supplementary Note:
Trans. of Zeitschrift fuer Immunitaetsforschung, Allergie und Klinische Immunologie (Germany), v76 p187-201, 1932.,
Pages:
0013
Distribution Statement:
Approved for public release; distribution is unlimited. Document partially illegible.
File Size:
0.67MB
