The serum of 11 patients suffering from pulmonary plague, and the serum of 25 patients suffering from bubonic plague, were studied. From the onset of the disease, a significant decrease of albumin and an increase of globulins, particularly gamma-globulins, was demonstrated. Three months after recovery, the electrophoretic pattern returned to normal. In sera of patients recovered from bubonic plague, the immunoelectrophoretic analysis showed the presence of a globulin migrating with the specific anti-plague gamma-globulin. This globulin is constituted, according to the moment of the disease, of a certain number of antibodies, corresponding to antigens determined on the P. pestis immunoelectrophoretic diagram. The lines i, c e seem to appear first then the lines b, j, k, then or according to the severity of the disease, the line b benign disease, j, k toxic infection. These lines disappear in an inverse order of their appearance, and all of them disappear 18 months after the end of the disease.
Trans. of Institut Pasteur, Paris. Annales (France) v106 p236-248 1964.