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Accession Number:
AD0837171
Title:
THE EFFECTS OF ANTIBIOTICS, CORTICOSTEROIDS, AND PERITONEAL LAVAGE ON EXPERIMENTAL PERITONITIS,
Corporate Author:
WALTER REED ARMY INST OF RESEARCH WASHINGTON DC
Report Date:
1968-01-01
Abstract:
The effectiveness of antibiotics, corticosteroids and peritoneal lavage on experimental peritonitis in the rat depends upon the time of initiation of treatment. Compared with untreated controls, treatment with antibiotics was ineffective after 8 hours or 12 hours, and peritoneal lavage was totally ineffective 12 hours after the E. coli-hemoglobin inoculation. In contrast, dexamethasone provided protection even at 16 hours after inoculation. Combined treatments of dexamethasone and antibiotic or peritoneal lavage was no more effective than dexamethasone alone. However, the combined peritoneal lavage and kanamycin treatment at 12 hours after inoculation, increased survival significantly over a peritoneal lavage alone. The beneficial effects of dexamethasone could be attributed in part to increased peritonela absorption. Author
Pages:
0011
File Size:
0.00MB
