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EXPERIMENTAL HEMORRAGIC FEVER IN GUINEA PIGS (JUNIN VIRUS) CONTAGION AND ELIMINATION OF VIRUS
ARMY BIOLOGICAL LABS FREDERICK MD
A study was made of the possibility of contamination between infected and normal guinea pigs, the infection of guinea pigs by air borne-route and the elimination of virus by urine and stools of infected animals. Normal guinea pigs were exposed to infection by placing them in the same cage and in neighboring ones to the cages of inoculated guinea pigs 16 strains of Junin virus were employed. The 100 of inoculated guinea pigs died with the typical signs of AHF. Only the 11.3 of normal guinea pigs placed in the same cage were infected. This means that the 31 of the strains employed contaminated the normal animals. None of the normal animals placed in neighboring cages died. By inoculating guinea pigs with daily urine samples taken from guinea pigs infected with Junin virus strain XJ it was found that the virus appears in urine from the 7th day after the inoculation. The virus was not isolated from stools of infected animals. Four guinea pigs were infected by nebulization with a suspension of the virus. The animals died with the typical signs of AHF.
Trans. of Revista de la Asociacion Medica Argentina, v79 p271-4 1965. DOI: 10.21236/AD0835855