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RESULTS OF A STUDY MADE OF OMSK HEMORRHAGIC FEVER (OL) BY AN EXPEDITION OF THE INSTITUTE OF NEUROLOGY
ARMY BIOLOGICAL LABS FREDERICK MD
Valuable material was collected concerning the clinical, laboratory, pathomorphological and epidemiological characteristics of Omsk disease. It was demonstrated that steppe ticks, Dermacentor pictus, which were collected in the regions where there were cases of Omsk fever, contain the virus of Omsk fever and therefore may be sources of infection for man, whom they attack. Immunity to Omsk fever was developed in those who were vaccinated with the killed virus, which makes it possible to make practical use of vaccinated to combat this disease. Experiments on monkeys, mice, and others testified to the absence of cross immunological reactions between the virus of Omsk fever and that of Crimean hemorrhagic fever and, therefore to the etiological individuality of each of these infections, which appeared similar, but are not identical to each other. Experiments on cross immunity in guinea pigs and the results obtained from regular pathological investigations established a clear differentiation between the virus of Omsk fever and the filtrable virus of the rickettsial type such as Q-fever or the so-called atypical virus pneumonia. A practical method of sero-diagnosis of separate cases of Omsk fever and diseases suspected to be Omsk fever was established by using complement fixation reactions and neutralization tests of the virus with specific serum.
Trans. of Akademiya Nauk Meditsinskikh Nauk SSSR. Vestnik, v2 p19-26 1948.