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ALTERATION OF THE PENETRABILITY OF SKIN.
LEVER BROS CO EDGEWATER NJ RESEARCH AND DEVELOPMENT DIV
The studies presented in this report have been directed toward devising techniques to 1 enhance the barrier properties of the skin, and 2 to evaluate means of increasing the permeability of skin. Lipid-protein complexes formed by the reaction of oxidized, unsaturated fatty acids with proteins are being evaluated as a means for protecting and strengthening the skin barrier. Such complexes may be formed in the course of keratinization. Some evidence for this has been obtained by the isolation and characterization of a complex polar lipid, consisting of sterol, fatty acid and peptide. A gas-liquid chromatographic procedure has been developed for the analysis of sterols in skin lipids. Lipid fractions from neonatal rat stratum corneum have been evaluated for activity in improving the barrier properties of skin. Evaluation of the most polar fraction of lanolin has shown that it provides good protection against croton oil irritation. Examination of solvent-damaged stratum corneum by electron microscopy has revealed a correlation between increased water permeability and alterations in desmosomes and cell membrane morphology. A technique has been developed to study the diffusion of gases through skin. Preliminary results on the diffusion of helium through skin indicate that the pilosebaceous duct may be an important route of entry for this gas. Author
Semi-annual rept. 24 Jan-24 Jul 66,