The administration of lead acetate PbAc2 sensitizes both rats and subhuman primates to minute amounts of bacterial endotoxin. The mechanism of this sensitization has not been defined, although it has been suggested that alterations in either the degradation of endotoxin, or in carbohydrate metabolism, may be important. Glucocorticoids are demonstrably effective in protecting normal animals against endotoxin. The purpose of the present investigation was to determine if this was also the case in lead-sensitized animals.
Medical research progress rept. no. 1,
Pub. in Infection and Immunity, v8 n4 p683-684 Oct 1973.