Accession Number:

AD0753932

Title:

Increased Rates of Sugar Transport in 'Saccharomyces cerevisiae': A Result of Sugar Metabolism.

Personal Author(s):

Corporate Author:

ARMY MEDICAL RESEARCH LAB FORT KNOX KY

Report Date:

1972-08-21

Abstract:

Preincubation of yeast cells with glucose or other metabolic energy source increased rates of sorbose efflux and uptake. Stimulated rates persisted for several hours, decreasing slowly. Transport of arabinose and fucose also occurred at increased rates, whereas uptake of dimethylsulfoxide, which enters the cell by simple diffusion, was not changed. Efflux rates were approximately halved by including Km concentrations of highly competitive sugars, such as deoxyglucose, glucose, fructose and mannose in sorbose efflux suspensions, and were greatly slowed at reduced temperatures. Inhibitors of energy metabolism blocked the rate stimulation, as did cycloheximide added nitrogen sources increased the rate additionally. The data indicate a change in the sorbose transport system rather than in membrane permeability. The change, perhaps the synthesis of a transport system component, evidently requires metabolic energy and involves protein synthesis. Author

Descriptive Note:

Final rept.,

Pages:

0020

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File Size:

0.00MB

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