ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD
Small- and large-plaque variants of a Florida strain Fe 3-7c of Venezuelan equine encephalomyelitis virus were studied in vivo and in vitro. The small-plaque variant was less virulent in mice, hamsters, and guinea pigs than the large-plaque variant. The variants could be distinguished by calcium phosphate chromatography. The implications of plaque variants within a mixed virus population are discussed.
Pub. in Infection and Immunity, v6 n5 p779-784 Nov 1972.