DID YOU KNOW? DTIC has over 3.5 million final reports on DoD funded research, development, test, and evaluation activities available to our registered users. Click
HERE to register or log in.
Accession Number:
AD0743923
Title:
Effect of Prostaglandin El on the Pulmonary Vascular Response to Endotoxin
Corporate Author:
OKLAHOMA UNIV HEALTH SCIENCES CENTER OKLAHOMA CITY DEPT OF PHARMACOLOGY
Report Date:
1972-05-31
Abstract:
Endotoxin causes an increase in vascular resistance and the release of some lysosomal enzymes in the circulation of the isolated lobe of the dog lung perfused in situ. These effects of endotoxin were prevented by the administration of PGE sub 1. When PGE sub 1 was infused after endotoxin was given, the increase in the pulmonary perfusion pressure was greatly reduced. Thus similar to the previously tested anti-inflammatory drugs, PGE sub 1 can block some of the effects of endotoxin in the circulation.
Descriptive Note:
Technical rept.
Supplementary Note:
Sponsored in part by Grants PHS-HE-08764 and PHS-HE-05859.
Pages:
0016
Distribution Statement:
Availability: Document partially illegible.
Contract Number:
N00014-69-A-0385-0003
Contract Number 2:
N00014-68-A-0496
File Size:
0.57MB
