The po toxicity of propylene glycol 1,2-dinitrate PGDN in rats and the ocular and dermal irritation effects of PGDN on rabbits were determined. Rats, guinea pigs, rabbits, squirrel monkeys and dogs were exposed to the vapors of PGDN in acute, repeated and continuous inhalation exposures. Physiological and biochemical changes noted were anemia, pigment deposition in various organs, fatty changes in the liver, methemoglobin formation, and greatly increased serum and urinary inorganic nitrates. The effect of PGDN on the avoidance behavior of trained rhesus monkeys was also studied.
Pub. in Toxicology and Applied Pharmacology, v22 p128-137, 1972.