Accession Number:

AD0743580

Title:

Toxicity of Propylene Glycol 1,2-Dinitrate in Experimental Animals

Corporate Author:

NAVY TOXICOLOGY UNIT BETHESDA MD

Report Date:

1971-08-12

Abstract:

The po toxicity of propylene glycol 1,2-dinitrate PGDN in rats and the ocular and dermal irritation effects of PGDN on rabbits were determined. Rats, guinea pigs, rabbits, squirrel monkeys and dogs were exposed to the vapors of PGDN in acute, repeated and continuous inhalation exposures. Physiological and biochemical changes noted were anemia, pigment deposition in various organs, fatty changes in the liver, methemoglobin formation, and greatly increased serum and urinary inorganic nitrates. The effect of PGDN on the avoidance behavior of trained rhesus monkeys was also studied.

Descriptive Note:

Journal article

Supplementary Note:

Pub. in Toxicology and Applied Pharmacology, v22 p128-137, 1972.

Pages:

0010

Subject Categories:

Distribution Statement:

Approved for public release; distribution is unlimited.

File Size:

0.56MB