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ON THE CONTROL OF URINE FORMATION,
RAND CORP SANTA MONICA CALIF
A presentation of mathematical and physicochemical models of the intrinsic renal control of body water and electrolytes. On the basis of these models, Jacobian Matrices are prepared which assist in predicting local qualitative changes in body water and electrolytes in response to various forms of chemical stress. The results obtained in certain specific examples compare favorably with those of reported physiological experiments. The Paper discusses the usefulness and limitations of these models, and describes various methods for introducing time into them--the most useful one being that in which the flux of metabolites is derived from the composition and flow of urine. Author