Accession Number:

AD0623005

Title:

INCREASED PLASMA-CHOLINESTERASE ACTIVITY AND SUCCINYLCHOLINE RESISTANCE: A GENETIC VARIANT.

Personal Author(s):

Corporate Author:

CHEMICAL RESEARCH AND DEVELOPMENT LABS EDGEWOOD ARSENAL MD

Report Date:

1965-10-01

Abstract:

Plasma-cholinesterase activity was determined in medical-volunteer-program subjects. In 1,029 subjects, activity varied from 92 to 1,278 micromoles ACH hydrolyzedhr, with a mean of 391 micromoles. Plasmacholinesterase activity in one subject was consistently elevated. Examination of his family revelaed that this activity was inherited in an autosomal, dominant manner. In vitro and in vivo studies suggested that the propositus was heterozygous for an enzyme molecule more than three times as active as the usual cholinesterase. The pharmacological effect of this genetic variation is discussed. Author

Descriptive Note:

Rept. for Aug 64-Jun 65,

Pages:

0027

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0.00MB

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