Accession Number:

AD0612474

Title:

SYNTHESIS OF 7-METHYL-2-OXO-2,4,5,6-TETRAHYDROPYRROLO (1,2-C) PYRIMIDINE

Personal Author(s):

Corporate Author:

CHEMICAL RESEARCH AND DEVELOPMENT LABS EDGEWOOD ARSENAL MD

Report Date:

1964-11-01

Abstract:

As part of a study for the elucidation of the structure of saxitoxin, the synthesis was undertaken of a possible C8 fragment resulting from the degradation of the natural product. The preparation of 7-methyl-2-oxo2,4,5,6- tetrahydropyrrolo 1,2-c-pyrimidine, a new ring system, is described. The selective oxidation to the desired 7-methyl-2-oxo-2,4,5,6-tetrahydropyrrolo1,2- c pyrimidine was accomplished with a dilute neutral aqueous solution of potassium permanganate at room temperature overnight. The physical and analytical properties of 7-methyl-2-oxo-2,4,5,6-tetrahydropyrrolo1,2-c pyrimidine were not identical with those of the product obtained from the natural product. The 8-methyl derivative is the correct structure of one of the degradation products of saxitoxin.

Descriptive Note:

Technical rept. for Sep 1960-Jun 1961

Supplementary Note:

The work was performed in conjunction with Contract DA18 108CML5998. DOI: 10.21236/AD0612474

Pages:

0015

Identifiers:

Subject Categories:

Communities Of Interest:

Distribution Statement:

Approved for public release; distribution is unlimited.

File Size:

0.81MB