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Accession Number:
AD0612164
Title:
INFLUENCE OF TRAUMA AND HEMOLYSIS ON HEMORRHAGIC SHOCK IN DOGS,
Corporate Author:
WALTER REED ARMY INST OF RESEARCH WASHINGTON D C
Report Date:
1963-01-01
Abstract:
A small amount 20 ml. of endogenous hemolyzed blood causes an increase in mortality of dogs in hemorrhagic shock from 13 to 91. This lethal effect is due to the stimulation by hemolyzed blood of disseminated intravascular coagulation DIC, 3 which is also stimulated by hemorrhage and shock. The lethal factor is a clotting factor in the red cell. Large amounts 100 ml. of hemolyzed blood alone is harmless, but even a small amount 20 ml. is lethal in the presence of shock. Hemolyzed blood causes the conversion of fibrinogen to fibrin. Fibrinolysin will prevent death in irreversible hemorrhagic shock both as produced by hemorrhage alone 10 or as influenced by hemolyzed blood. Endogenous heparin is stimulated by DIC which is produced either by hemorrhage alone, hemolyzed blood alone, or by a combination of both. It is probably a protective mechanism. A markedly prolonged silicone clotting time occurring during hemorrhagic shock is an accurate prognostication of irreversibility. Irreversibility is correlated with a fibrinogen fall, when the fibrinogen fall is due to consumption in DIC. Central venous pressure is not elevated even though the shock is proven to be irreversible. Irreversibility is due to an episode of DIC. 3
Supplementary Note:
Also included in Proceedings of the 1964 Army Science Conference, United States Military Academy, West Point, N. Y., 17-19 Jun 64, Volume I, AD-611 432.
Pages:
0015
File Size:
0.00MB
