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MOLECULAR MECHANISMS OF ANTIMICROBIAL ACTION,
WALTER REED ARMY INST OF RESEARCH WASHINGTON D C
Antibiotics have been found to inhibit 1 cellwall synthesis penicillin, 2 protein synthesis chloramphenicol, tetracyclines, streptomycin, erythromycin, 3 RNA synthesis, and 4 DNA synthesis. Mechanisms by which these effects are produced have been studied and typical results of this research are reported. Chloramphenicol and erythromycin appear to inhibit protein biosynthesis by direct interaction with ribosomes. In all instances, the antimicrobial actions occurred in the general area of macromolecular biosynthesis and assemblage.
Also included in Proceedings of the 1964 Army Science Conference, United States Military Academy, West Point, N. Y., 17-19 Jun 64, Volume I, AD-611 432.